The biocleavage of alkyl glyceryl ethers in Morris hepatomas and other transplantable neoplasms.

Abstract

This study compares the ether-cleaving ability of normal rat liver homogenate with various transplantable tumor homogenates. The results show that the cleavage system is the most active in normal rat liver and Morris Hepatoma 7794A, much less active in Hepatoma 7777, and very low or absent in the other tumors tested. These data demonstrate that neoplasms that contain high levels of O -alkyl-diacylglycerols do not have an active alkyl ether cleavage system.