Secondary Metabolites from the Fungus <i>Chaetomium brasiliense</i>

Abstract

Abstract Two new depsidones, mollicellins I and J ( 1 and 2 , resp.), and a new chromone, 2‐(hydroxymethyl)‐6‐methylmethyleugenin ( 3 ), along with six known compounds, 4 – 9 , were isolated from the ethyl acetate extract of a solid‐state fermented culture of Chaetomium brasiliense. Their structures were elucidated based on spectroscopic analysis. Mollicellins I and H ( 5 ) exhibited significant growth inhibitory activity against human breast cancer (Bre04), human lung (Lu04), and human neuroma (N04) cell lines with GI 50 values between 2.5–8.6 μg/ml.