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Antitumor effect of intracutaneous injection of bacterial lipopolysaccharide.
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1968
Year
InflammationClearing ActivityAntibioticsSummary Intracutaneous InjectionMedicineImmunologyTumor ImmunityPathologyTherapeutic EfficacyVascular BiologySarcoma 180Tumor TargetingAntimicrobial CompoundImmunosuppressionImmunotherapyPharmacologyTumor MicroenvironmentAntitumor Effect
Summary Intracutaneous injection of the lipopolysaccharide of Proteus vulgaris was found to stimulate the reticuloendothelial system and have a marked antitumor effect in mice bearing solid-type Ehrlich carcinoma and Sarcoma 180. The stimulation of the reticuloendothelial system was tested by measuring the clearing activity of intravenously injected colloidal carbon in mice. Of the various routes of injection tested, the actions of lipopolysaccharide were observed most after intracutaneous injection. Two possible modes of action of lipopolysaccharide were indicated: one is a stimulation of the reticuloendothelial system which can be expected to provoke subsequent antibody formation, and the other action is a direct cytocidal action.