Amide Formation Using In Situ Activation of Carboxylic Acids with [Et₂NSF₂]BF₄

Abstract

Abstract The formation of amides through the in situ activation of carboxylic acids with [Et 2 NSF 2 ]BF 4 is presented. A wide range of carboxylic acids and amines were used to produce the corresponding amides in up to 99 % yield. The reaction of hindered amines was also possible in the presence of 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) under slightly modified conditions. An enantiopure carboxylic acid and amine were both shown to react without racemization.