Localization of human GW-39 tumors in hamsters by radiolabeled heterospecific antibody to carcinoembryonic antigen.

Abstract

Summary The in vivo localization of radiolabeled heterospecific antibody to carcinoembryonic antigen (CEA) was investigated in a human colonic tumor-hamster host model. With the paired-labeled antibody technique, a significant and specific accumulation of goat anti-CEA immunoglobulin G (IgG) was observed in small tumors ( 5.0 g) failed to show preferential uptake of anti-CEA IgG, it is suggested that circulating antigen and/or hamster antibody against CEA interfere with the accumulation of localizing antibody in larger tumors.