PubMed · 1973 · 121 citations · 12 references
MedicineCancer BiologyOncologyGastrointestinal OncologyMonoclonal AntibodiesNeoplasiaAntibody CharacterizationImmunohistochemistryMalignant NeoplasmsTumor AntigensTumor-associated AntigensAntigen-antibody InteractionsAntigen-antibody RecognitionCancer AntigensMonoclonal Antibodies In CancerMonoclonal Antibodies In OncologyOrgan-specific AccumulationRadiolabeled Antibody Imaging
Summary The in vivo localization of radiolabeled heterospecific antibody to carcinoembryonic antigen (CEA) was investigated in a human colonic tumor-hamster host model. With the paired-labeled antibody technique, a significant and specific accumulation of goat anti-CEA immunoglobulin G (IgG) was observed in small tumors ( 5.0 g) failed to show preferential uptake of anti-CEA IgG, it is suggested that circulating antigen and/or hamster antibody against CEA interfere with the accumulation of localizing antibody in larger tumors.
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