Direct Substitution of Hydroxy Group of π-Activated Alcohols with Electron-Deficient Amines Using Re₂O₇ Catalyst

Abstract

The first example of simple Re(2)O(7)-catalyzed direct dehydrative coupling between allylic alcohols with electron-deficient amines has been achieved under mild and open flask conditions. The protocol has also been successfully applied to benzylic and propargylic alcohols. The mechanistic proof for the S(N)1-type process has also been provided.