Synthesis of 7-aminoguanosine and its conversion to 8-substituted derivatives.

Abstract

Guanosine is aminated with 2, 4-dinitrophenoxyamine in DMF-H2O to form 7-aminoguanosine which is readily converted mainly to 8, 5'-O-cycloguanosine and 8-hydroxyguanosine by warming in H2O. The aminated product from deoxyguanosine is 7-aminoguanine.