Functional interactions between 5‐HT_2Aand presynaptic 5‐HT_1Areceptor‐based responses in mice genetically deficient in the serotonin 5‐HT transporter (SERT)

Abstract

These data show that indirect activation of 5-HT(2A) receptors via blockade of presynaptic 5-HT(1A) receptors potentiated head-twitch responses, suggesting functional interactions between these receptors, interactions affected by altered 5-HT availability. Our findings strongly support the correlation of WAY 100635 induced head twitches with increased 5-HT availability, induced genetically or pharmacologically.