Elevation of a serum component in neoplastic disease.

Abstract

1. A procedure has been formulated for the assay of a serum component which catalyzes the oxidation of reduced diphosphopyridine nucleotide and the simultaneous reduction of pyruvic acid to lactic acid. 2. The activity of the sera producing this oxidation-reduction change has been found to be low in healthy individuals and in patients with a number of pathological conditions. It is elevated in neoplastic disease and in pregnancy.