The Use of Surfactants to Enhance the Permeability of Peptides Through Caco-2 Cells by Inhibition of an Apically Polarized Efflux System

Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

Ismael J. Hidalgo, Thomas J. Raub, Ronald T. Borchardt · Gastroenterology · 1989 · 2.2K citations

Life Sciences, Cell Biology, Oncology +14

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Carlos Cordon‐Cardo, James P. O’Brien, D Casals et al. · Proceedings of the National Academy of Sciences · 1989 · 1.7K citations · Full text

Medicine, Oncology, Pharmacology +16

Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability

Ismael J. Hidalgo, Thomas J. Raub, Ronald T. Borchardt · Gastroenterology · 1989 · 1.1K citations

Life Sciences, Cell Biology, Oncology +14

Epithelial Transport Of Drugs In Cell Culture. I: A Model For Studying The Passive Diffusion Of Drugs Over Intestinal Absorbtive (Caco-2) Cells

Per Artursson · Journal of Pharmaceutical Sciences · 1990 · 836 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17

Caco-2 Cell Monolayers as a Model for Drug Transport Across the Intestinal Mucosa

Allen R. Hilgers, Robert A. Conradi, Philip S. Burton · Pharmaceutical Research · 1990 · 582 citations

Pharmacy, Pharmaceutics, Pharmacology +15