Prognostic significance of copy number alterations in adolescent and adult patients with precursor <scp>B</scp> acute lymphoblastic leukemia enrolled in <scp>PETHEMA</scp> protocols

Abstract

Deletions of EBF1, IKZF1, and CDKN2A/B have an independent adverse prognosis for adolescents and adults with B-precursor ALL, and this suggests that these CNAs should be included in the initial risk assessment of ALL.