Human sulfatase‐1 inhibits the migration and proliferation of SMMC‐7721 hepatocellular carcinoma cells by downregulating the growth factor signaling

Abstract

The expression of hSulf-1 mediated by adenovirus in HCC cells could downregulate the activity of AKT and ERK signaling pathways, and inhibit HCC cell migration and proliferation. The hSulf-1 gene may be considered as a candidate of antitumor factor for cancer gene therapy.