SULFADIAZINE; FURTHER CLINICAL STUDIES OF ITS EFFICACY AND TOXIC EFFECTS IN 460 PATIENTS

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Article1 December 1942SULFADIAZINE; FURTHER CLINICAL STUDIES OF ITS EFFICACY AND TOXIC EFFECTS IN 460 PATIENTSMAXWELL FINLAND, M.D., F.A.C.P., OSLER L. PETERSON, M.D., ROBERT A. GOODWIN JR., M.D.MAXWELL FINLAND, M.D., F.A.C.P.Search for more papers by this author, OSLER L. PETERSON, M.D.Search for more papers by this author, ROBERT A. GOODWIN JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-6-920 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEvidence for the effectiveness of sulfadiazine in many of the common bacterial infections has now been obtained in several large clinics by a number of observers, all of whom have attested to the relatively low toxicity of this drug.1, 2, 3, 4, 5Since the time of our earlier publication on this subject,2the use of sulfadiazine at the Boston City Hospital was limited largely to those groups of cases in which additional data seemed desirable. In this paper we wish to summarize the past year's experience with the clinical use of sulfadiazine at this hospital and, in so doing,...References1. FLIPPINROSESCHWARTZDOMM HFSBLAH: Sulfadiazine and sulfathiazole in the treatment of pneumococcic pneumonia. A progress report on 200 cases, Am. Jr. Med. Sci., 1941, cci, 585-592. CrossrefGoogle Scholar2. FINLANDSTRAUSSPETERSON MEOL: Sulfadiazine: therapeutic evaluation and toxic effects in four hundred and forty-six patients, Jr. Am. Med. Assoc., 1941, cxvi, 2641-2647. CrossrefGoogle Scholar3. DOWLINGHARTMANSUGARFELDMAN HFCRSJHA: The treatment of pneumococcic pneumonia with sulfadiazine, Ibid., 1941, cxvii, 824-826. Google Scholar4. TREVETTNELSONLONG GIRAPH: Studies on sulfadiazine. II. The clinical use of sulfadiazine in the therapy of bacterial infections, other than pneumonia, Bull. Johns Hopkins Hosp., 1941, lxix, 303-313. Google Scholar5. BILLINGSWOOD FTWB: Studies on sulfadiazine. III. The use of sulfadiazine in the treatment of pneumococcal pneumonia, Ibid., pp. 314-326. Google Scholar6. FINLANDSTRAUSSPETERSON MEOL(a) : Staphylococcal pneumonia occurring during an epidemic of clinical influenza, Trans. Assoc. Am. Phys., 1941, lvi, 139-144. (b) FINLAND, M., PETERSON, O. L., and STRAUSS, E.: Staphylococcic pneumonia occurring during an epidemic of influenza, Arch. Int. Med., 1942, lxx, 183-205. Google Scholar7. WHITEHOUSEWATKINS FRCH: Acute thrombocytopenic purpura following sulfadiazine therapy: report of a case, Proc. Staff Meet. Mayo Clin., 1942, xvii, 140-143. Google Scholar8. LEHRANTOPOL DW(a) : Typical urinary crystals of three sulfanilamide derivatives produced in vitro , Science, 1941, xciv, 282-283. (b) IDEM: Specific morphology of crystals appearing in the urine during administration of sulfanilamide derivatives, Am. Jr. Clin. Path., 1942, xii, 200-209. CrossrefGoogle Scholar9. SCHWARTZFLIPPINREINHOLDDOMM LHFJGAH: The effect of alkali on crystalluria from sulfathiazole and sulfadiazine, Jr. Am. Med. Assoc., 1941, cxvii, 514-515. CrossrefGoogle Scholar10. THOMPSONHERRELLBROWN SJWEAE: Anuria after sulfadiazine therapy, Proc. Staff Meet. Mayo Clin., 1941, xvi, 609-612. Google Scholar11. BRADFORDSHAFFER HAJH: Renal changes in a case of sulfadiazine anuria, Jr. Am. Med. Assoc., 1942, cxix, 316-318. CrossrefGoogle Scholar12. SCHULTESHIDLERNIEBAUER JWFPJJ: Acute urinary suppression following sulfadiazine therapy, Ibid., 1942, cxix, 411-413. Google Scholar13. RAINES SL: Ureteral obstruction following the use of sulfadiazine, Ibid., 1942, cxix, 496-497. Google Scholar14. LYONSBALBEROR RHH: Febrile reactions accompanying the readministration of sulfathiazole, Ibid., 1942, cxviii, 955-958. Google Scholar15. CURRY JJ: Acute agranulocytosis following sulfadiazine, Jr. Am. Med. Assoc., 1942, cxix, 1502. CrossrefGoogle Scholar16. BYNUMJOYCEPYLE WTFTOS: Anuria following the administration of sulfadiazine and sulfapyridine: Case report, Oklahoma State Med. Jr., 1942, xxxv, 145-147. Google Scholar17. MOLLATHBELTEBERT ALECE: Anuria due to sulfadiazine crystals, California and West. Med., 1942, lv, 355. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MAXWELL FINLAND, M.D., F.A.C.P.; OSLER L. PETERSON, M.D.; ROBERT A. GOODWINJR., M.D.Affiliations: Boston, Massachusetts*Received for publication July 15, 1942.From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital, and the Department of Medicine, Harvard Medical School, Boston.This study was carried out with the generous coöperation of the staffs of the various clinical and laboratory services throughout the hospital. The sulfadiazine was supplied by the Lederle Laboratories, Inc. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProlonged Treatment of Urinary-Tract Infections with SulfamethoxypyridazineChemotherapeutic and antibiotic drugs in the management of infections of the urinary tractHemocytopenic Reactions to Modern DrugsSulfonamide HematuriaAntibacterial ChemotherapyIncidence of reactions to sulfonamide drugs in infants and childrenSULFONAMIDES IN DERMATOLOGY*Comparative toxicities of sulfadiazine and sulfathiazole in children 1 December 1942Volume 17, Issue 6 Page: 920-934 Keywords Adverse reactions Clinical laboratories Hospital medicine Hospitals Medical services Research laboratories Toxicity ePublished: 1 December 2008 Issue Published: 1 December 1942 PDF downloadLoading ...