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A PMN-derived factor that enhances DNA-synthesis in PHA or antigen-stimulated lymphocytes.
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1980
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Knockout MousePmn FactorLymphocyte DevelopmentGranulocyteImmunologyMolecular BiologyAntigen-stimulated LymphocytesPmn Potentiation FactorImmunologic MechanismImmunomodulationInnate ImmunityImmune SystemMedicineCell BiologyCell SignalingCellular PhysiologyPmn-derived FactorDna Synthesis Potentiation
The DNA synthesis potentiation of a mouse polymorphonuclear leukocyte (PMN) factor was studied by using phytohemagglutinin (PHA)-stimulated syngeneic thymocytes. The partially purified PMN factor was nonmitogenic and exhibited maximum potentiation of thymocytes when added within 3 hr of PHA stimulation. PHA-stimulated, but not nonstimulated thymocytes absorbed PMN potentiation factor. 125I-labeled factor binding to stimulated thymocytes was observed. Our results suggest that an acceptor site for PMN factor may be generated on the thymocyte surface only after PHA stimulation.