Stimulation of the Neutral Activity of Rabbit Liver Fructose 1,6-Diphosphatase by Fatty Acids

Abstract

Various fatty acids markedly stimulated rabbit liver fructose 1,6-diphosphatase neutral activity. Oleate was the most effective both in terms of Ka and Vmax. The 10-fold activation of the enzyme by rabbit liver pH 6 precipitate can be completely accounted for by the free fatty acids found in such preparations.