Studies on Pyridazine Derivatives. I. Synthesis and Antimicrobial Activity of 6-Substituted 3-Aminopyridazine and its Sulfonamido Derivatives

Abstract

To find more improved sulfonamide drugs, 3-sulfanilyl-6-hydroxy-, 3-sulfanilyl-6-mercapto-, 3-sulfanilyl-6-alkoxy-and 3-sulfanilyl-6-alkylthio-pyridazine and their intermediates, 3-amino-6-hydroxy-, 3-amino-6-mercapto-, 3-amino-6-alkoxy- and 3-amino-6-alkylthio-pyridazine were synthesized. Few synthetic procedures via different routes were examined as to the synthesises of 3-sulfanilyl-6-alkoxy-, 3-sulfanilyl-6-alkylthio-and 3-amino-6-methoxy-pyridazine.Activities of the compounds of 6-substituted-3-sulfanilyl-pyridazine on some kinds of bacteria and viruses were examined and among thern, 3-sulfanilyl-6-methoxy-, 3-sulfanilyl-6-ethoxy and 3-sulfanilyl-6-methylthiopyridazine were found to exert remarkableantibacterial effects.