Induced resistance to an indigenous transplantable mouse tumor.

Abstract

Partial resistance has been induced in an inbred strain of mice (DBA/1) by the subcutaneous injection, and complete resistance by the intravenous injection, of suspensions of viable dbrB adenocarcinoma, a transplantable tumor indigenous to this strain. The resistance can be masked by the use of too large a challenge dose. The degree of resistance is dependent on the amount of material injected initially as the immunizing dose in the subcutaneous series of experiments. Intravenous administration is more effective, requiring only a fraction of the material needed for immunization by the subcutaneous route. The resistance to a challenge implant of tumor tissue is independent of the size attained by the primary tumor. Resistance to a challenge tumor appears to be, at least in part, the result of a reaction of the host to a primary implant, requiring between 4 and 18 days to become effective.