The Journal of Immunology · 1971 · 18 citations · 0 references
Life SciencesImmunologyOncologyCancer ImmunologyTumor ImmunologyTumor PathologyHistocompatibility AntigensOncogenic VirusesTumor AntigensTumor-associated AntigensAnimal ImmunizationImmunogenicity Of Tumor AntigensT-cell Responses To Tumor AntigensTumor Antigen ImmunogenicityTumor ImmunogenicityTumor Rejection AntigensViral Tumor Antigens
Abstract Two cell lines were derived from a hamster tumor induced by SV40 which differ in their ability to form tumors in SV40-immunized animals. Both lines contained SV40 T and S antigens. The immunosensitive cell line (H-50 IS) was rejected by SV40-immunized animals, whereas the immunoresistant cell line (H-50 IR) produced tumors in SV40-immunized animals. H-50 IR cells contain SV40-specific transplantation antigens since they immunized hamsters against a challenge by the immunosensitive line; these cells were highly transplantable, and tumors appeared earlier than did those produced by the H-50 IS line. Both cell lines grew at similar rates in vitro, and were inhibited equally by SV40 immune sera in the colony inhibition test.