Chronic treatment <i>in vivo</i> with β‐adrenoceptor agonists induces dysfunction of airway β₂‐adrenoceptors and exacerbates lung inflammation in mice

Abstract

This animal model reproduced salient features of human asthma and linked loss of bronchoprotection with airway pathobiology. Accordingly, the model offers an advanced tool for understanding the mechanisms of the effects of chronic β- agonist treatment on β-adrenoceptor function in asthma. Such information may guide the clinical use of β-agonists and provide insight into development of novel β-adrenoceptor ligands for the treatment of asthma.