The fragile genes <i>FHIT</i> and <i>WWOX</i> are inactivated coordinately in invasive breast carcinoma

Abstract

The strong correlation observed between Fhit and Wwox expression was consistent with the common elevated susceptibility of fragile sites to DNA damage. Reduced Fhit expression is associated with adverse prognostic factors. The current results suggest that Wwox also has an important and complex association with steroid hormone expression and breast carcinogenesis.