<scp>I</scp>mpact of leptin receptor gene variants on risk of non‐alcoholic fatty liver disease and its interaction with adiponutrin gene

Abstract

We report an association between variants of LEPR rs1137100 and rs1137101 with risk of NAFLD. This study suggests that rs1137100, specifically the G allele, is associated with a less severe form of liver disease in patients with NAFLD. The interaction between LEPR and PNPLA3 genes showed increased risk of NAFLD compared to either gene alone.