SUBACUTE BACTERIAL ENDOCARDITIS: ACTIVE CASES WITHOUT BACTEREMIA

Abstract

Article1 November 1937SUBACUTE BACTERIAL ENDOCARDITIS: ACTIVE CASES WITHOUT BACTEREMIACHESTER S. KEEFER, F.A.C.P.CHESTER S. KEEFER, F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-5-714 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor several years I have been interested in the group of patients with active bacterial endocarditis without bacteremia during life. These cases are not infrequent, and since organisms can be isolated from the vegetations post mortem, it is a matter of some interest to gather more information regarding the nature of the local lesion in the valves and the mechanism concerned with the absence of bacteremia.The relative incidence of these so-called "bacteria free"†1cases varies in the experience of different observers. In the last 54 cases of endocarditis which came to necropsy at the Boston City Hospital,‡the blood...References1. WRIGHT HD: The bacteriology of subacute infective endocarditis, Jr. Path. and Bact., 1925, xxviii, 541. CrossrefGoogle Scholar2. LIBMAN E: The clinical features of cases of subacute bacterial endocarditis that have spontaneously become bacteria-free, Am. Jr. Med. Sci., 1913, cxlvi, 625. LIBMAN, E.: Subacute bacterial endocarditis in the active and healing stages, Practical Lectures, 1925, Paul B. Hoeber, Inc., New York, p. 246. CrossrefGoogle Scholar3. BLUMGART HL: The clinical syndrome of subacute bacterial endocarditis involving the right chambers of the heart, Med. Clin. N. Am., 1933, xvi, 881. Google Scholar4. HAMMANRICH LVAR: Clinical pathological conference—two cases of bacterial endocarditis, Internat. Clin., 1933, ii, Series 43. Google Scholar5. BAEHR G: Renal complications of endocarditis, Trans. Assoc. Am. Phys., 1931, xlvi, 87. Google Scholar6. BAEHRLANDE G: Glomerulonephritis as a complication of subacute streptococcus endocarditis, Jr. Am. Med. Assoc., 1920, lxxv, 789. Google Scholar7. RICHBUMSTEADFROBISHER ARJM: Hemorrhagic glomerular lesions produced by filtrates of Streptococcus viridans cultures, Proc. Soc. Exper. Biol. and Med., 1929, xxvi, 397. CrossrefGoogle Scholar8. GROSSFRIEDBERG LCK: Nonbacterial thrombotic endocarditis. Classification and general description, Arch. Int. Med., 1936, lviii, 620. CrossrefGoogle Scholar9. FRIEDBERGGROSS CKL: Nonbacterial thrombotic endocarditis associated with acute thrombocytopenic purpura, Arch. Int. Med., 1936, lviii, 641. CrossrefGoogle Scholar10. FRIEDBERGGROSSWALLACH CKLK: Nonbacterial thrombotic endocarditis associated with prolonged fever, arthritis, inflammation of serous membranes and widespread vascular lesions, Arch. Int. Med., 1936, lviii, 662. CrossrefGoogle Scholar11. LEVINE SA: Clinical heart disease, 1936, W. B. Saunders Co., Philadelphia, Pa., p. 191. Google Scholar12. LEMANN I: Subacute bacterial endocarditis of the mitral valve previously rendered incompetent by infarction of the papillary, ANN. INT. MED., 1936, ix, 1587. Google Scholar13. LEARY T: Early lesions of rheumatic endocarditis, Arch. Path., 1932, xiii, 1. Google Scholar14. MALLORYKEEFER GKCS: Unpublished observations. Google Scholar15. VON GLAHNPAPPENHEIMER WCAW: Relationship between rheumatic and subacute bacterial endocarditis, Arch. Int. Med., 1935, lv, 173. CrossrefGoogle Scholar16. GRANTWOODJONES RTJETD: Heart valve irregularities in relation to subacute bacterial endocarditis, Heart, 1927-29, xiv, 247. Google Scholar17. LICHTMANGROSS SSL: Streptococci in the blood in rheumatic fever, rheumatoid arthritis and other diseases; based on a study of 5,233 consecutive blood cultures, Arch. Int. Med., 1932, xlix, 1078. CrossrefGoogle Scholar18. EPSTEINKUGEL EZMA: Significance of postmortem bacteriological examination, with special reference to streptococci and enterococci, Jr. Infect. Dis., 1929, xliv, 327. CrossrefGoogle Scholar19. SWIFTKINSELLA HFRA: Bacteriologic studies in acute rheumatic fever, Arch. Int. Med., 1917, xix, 381. CrossrefGoogle Scholar20. THAYER WS: Studies on bacterial (infective) endocarditis; introductory remarks and general considerations, Johns Hopkins Hosp. Rep., 1926, xxii, Fasc. 1. Google Scholar21. KINSELLA RA: Bacteriologic studies in subacute streptococcus endocarditis, Arch. Int. Med., 1917, xix, 367. CrossrefGoogle Scholar22. WRIGHT HD: The production of experimental endocarditis with pneumococci and streptococci in immunized animals, Jr. Path. and Bact., 1926, xxix, 5. CrossrefGoogle Scholar23. MILLERBRANCH CPA: Subacute bacterial endocarditis due to a hemolytic hemophilic bacillus; report of a case, Arch. Int. Med., 1923, xxxii, 911. CrossrefGoogle Scholar24. LIBMAN E: Observations on subacute streptococcus (and influenzal) endocarditis, Brit. Med. Jr., 1920, ii, 304. Google Scholar25. SWIFT HF: The heart in infection, Am. Heart Jr., 1928, iii, 629. CrossrefGoogle Scholar26. SPINKKEEFER WWCS: Unpublished observations. Google Scholar27. ROSENOW EC: Experimental infectious endocarditis, Jr. Infect. Dis., 1912, xi, 210. CrossrefGoogle Scholar28. KINSELLAGARCIA RAO: A clinical experiment in subacute streptococcus endocarditis, Proc. Soc. Exper. Biol. and Med., 1925, xxiii, 136. KINSELLA, R. A., and SHERBURNE, C. C.: Experimental production of streptococcus endocarditis, Jr. Am. Med. Assoc., 1923, lxxx, 1643. HERRMANN, R. G.: Experimental heart disease. II. The effect of experimental aortic regurgitation on the heart weights; with a consideration of some factors concerned in cardiac hypertrophy and a summary of the manifestations of experimental heart disease, Am. Heart Jr., 1926, i, No. 4. CrossrefGoogle Scholar29. WADSWORTH AB: A study of the endocardial lesions developing during pneumococcus infection in horses, Jr. Med. Res., 1919, xxxix, 279. Google Scholar30. PARKER F: Personal communication. Google Scholar31. HAMMANRIENHOFF LWF: Subacute Streptococcus viridans septicemia cured by excision of an arteriovenous aneurysm of the external iliac artery and vein, Bull. Johns Hopkins Hosp., 1935, lvii, 219. Google Scholar32. HOWELLSCORRIGAN KMM: Skin reactions with bacterial filtrates of anhemolytic streptococcus, hemolytic streptococcus, and B. typhosus , Jr. Infect. Dis., 1928, xlii, 149. CrossrefGoogle Scholar33. LEVINE SA: Clinical heart disease, 1936, W. B. Saunders Co., Philadelphia, Pa., p. 194. Google Scholar34. DERRICKFULTON CM: Skin reactions in patients and normal individuals to protein extracts of streptococci, Jr. Clin. Invest., 1931, x, 121. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHESTER S. KEEFER, F.A.C.P.Affiliations: Boston, Massachusetts*Read before the St. Louis meeting of the American College of Physicians, April 23, 1937.From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital, and the Department of Medicine, Harvard Medical School, Boston.†The term "bacteria free" cases was first introduced by Libman.2 Sometimes it refers to cases without bacteremia but with organisms in the heart valves. In other instances, the term has been further restricted to those cases in which one can not obtain bacteria from the heart valves at necropsy (healing or healed bacterial endocarditis).‡I am indebted to Dr. Parker, Director of the Mallory Institute of Pathology, for allowing me to use the records for this information. He has also been very generous in studying the sections of the heart valves with me. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiagnosis of Infective Endocarditis IDiagnostic methodsDiagnostic methodsInfective endocarditis with negative blood culturesTreatment of infective endocarditis—1973Negative Blood Cultures in Bacterial Endocarditis: A Decade's ExperienceCase 15-1964PHAGOCYTIC RETICULOENDOTHELIAL CELLS IN SUBACUTE BACTERIAL ENDOCARDITIS WITH NEGATIVE CULTURES*RICHARD W. HILL, M.D., EDWIN D. BAYRD, M.D.Die Herz- und GefäßkrankheitenFever of Unknown Origin IIDiagnosis and Prevention of Bacterial EndocarditisNiere und Sepsis lentaSubacute bacterial endocarditis in the agedThe Treatment of Nonhemolytic Streptococcus Subacute Bacterial Endocarditis with PenicillinSyphilitic cardiovascular disease and bacterial endocarditisThe pathogenesis of bacterial endocarditis 1 November 1937Volume 11, Issue 5Page: 714-734KeywordsBacteremiaBacteriaBloodEndocarditisHeartHospital medicineLesionsMedical servicesResearch laboratories ePublished: 1 December 2008 Issue Published: 1 November 1937 PDF downloadLoading ...