Anti-apoprotein B monoclonal antibodies detect human low density lipoprotein polymorphism.

Abstract

Immunochemical polymorphism among human low density lipoproteins (LDL) isolated from different individuals was demonstrated through reduced binding of three monoclonal antibodies to some individual LDL using a solid phase radioimmunoassay.These three antibodies are members of a larger group of monoclonal antibodies previously shown to bind specifically to apoprotein B (Curtiss, L. K., and Edgington, T. S .