Dominant IL‐10 and TGF‐β mRNA Expression in γδT Cells of Human Early Pregnancy Decidua Suggests Immunoregulatory Potential

Abstract

The present findings suggest that gammadeltaT cells in normal pregnancy create a cytokine milieu promoting immunotolerance to the fetus. We hypothesize that through the production of the immunosuppressive cytokines IL-10 and/or TGF-beta the gammadeltaT cells could function directly as regulatory T cells or induce the differentiation of Th0 TCRalphabeta+ cells into regulatory/suppresser cells.