Hydrogen sulfide inhibits the translational expression of hypoxia‐inducible factor‐1α

Abstract

H(2) S suppresses HIF-1α translation by enhancing eIF2α phosphorylation under hypoxia. The interaction of H(2) S and HIF-1α inhibits the angiogenic activity of vascular endothelial cells under hypoxia through the down-regulation of VEGF.