Comparison of intensity‐dependent inhibition of spinal wide‐dynamic range neurons by dorsal column and peripheral nerve stimulation in a rat model of neuropathic pain

Abstract

SCS and PNS may offer similar inhibition of short-term neuronal sensitization. However, only SCS attenuates spinal transmission of acute noxious inputs under neuropathic pain conditions. Our findings begin to differentiate peripheral from spinal-targeted neuromodulation therapies and may help to select the best stimulation target and optimum therapeutic intensity for pain treatment.