I148<scp>M</scp> variant in <i><scp>PNPLA</scp>3</i> reduces central adiposity and metabolic disease risks while increasing nonalcoholic fatty liver disease

Abstract

The I148M variant, although increasing the risk of NAFLD, was associated with reduced levels of central adiposity, BMI, serum triglycerides and insulin resistance, suggesting differential roles in fat storage and distribution according to cell types and metabolic status.