Concepedia

Resistance to dl-α-difluoromethylornithine by clinical isolates of Trypanosoma brucei rhodesiense

Cyrus J. Bacchi, Joanne Garofalo, Maryann Ciminelli, Donna Rattendi, Burt Goldberg, Peter P. McCann, Nigel Yarlett

Biochemical Pharmacology · 1993 · 54 citations · 35 references

DOI

Concepts

References

35

Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.

Anthony E. Pegg · PubMed · 1988 · 1.5K citations

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Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose

Sheila M. Lanham, D.G. Godfrey · Experimental Parasitology · 1970 · 1.3K citations

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Continuous Cultivation of Trypanosoma brucei Blood Stream Forms in a Medium Containing a Low Concentration of Serum Protein without Feeder Cell Layers

H. Hirumi, K. Hirumi · Journal of Parasitology · 1989 · 1K citations · Full text

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In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei

Alan H. Fairlamb, Graeme B. Henderson, Cyrus J. Bacchi et al. · Molecular and Biochemical Parasitology · 1987 · 177 citations

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Treatment of gambiense sleeping sickness in the Sudan with oral DFMO (DL-α-difluoromethylornithine), an inhibitor of ornithine decarboxylase; first field trial

Simon Van Nieuwenhove, Paul J. Schechter, J. Declercq et al. · Transactions of the Royal Society of Tropical Medicine and Hygiene · 1985 · 152 citations

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