FEBS Letters · 1985 · 23 citations · 20 references
Life SciencesBiochemistryEndocrinologyCell SignalingHormone BiochemistryNeuroendocrinologyGrowth HormoneHormone ReleaseHormone SecretionHypothalamic-pituitary AxisPituitary Gland FunctionPituitary HormonesHormonal Regulation Of GrowthHypothalamic-pituitary-growth AxisSomatostatin AnaloguesSomatostatin FunctionSomatostatin PharmacologySomatostatin PhysiologySomatostatin SignalingSomatostatin-mediated Inhibition
Human pancreatic growth hormone-releasing factor (GRF-44-NH2) stimulated growth hormone (GH) secretion and intracellular cyclic AMP levels in cultured pituitary cells from both sheep and rat. Somatostatin (SRIF), over a wide range of doses and time, showed no significant effect on the elevated cyclic AMP levels in sheep cells, but did block the GH release in a dose-dependent manner. In rat cells, however, SRIF inhibited GRF-stimulated cyclic AMP levels by 75% maximum (still 8-fold greater than the basal levels) and GH release to almost half the basal value. We conclude that somatostatin inhibits GRF-elevated cyclic AMP levels in rat pituitary cells but not in sheep cells.
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Growth Hormone-Releasing Factor from a Human Pancreatic Tumor That Caused Acromegaly
Roger Guillemin, Paul Brazeau, Peter Böhlen et al. · Science · 1982 · 1.3K citations
Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour
Jean Rivier, Joachim Spiess, Michael O. Thorner et al. · Nature · 1982 · 1.1K citations
Medicine, Endocrinology, Oncology +14