Prevalence of Multiple Drug Resistant Escherichia coli in Patients of Urinary Tract Infection Registering at a Diagnostic Laboratory in Lahore, Pakistan

Abstract

The prevalence and antibiotic susceptibility pattern of E. coli was analyzed in urine samples of patients with acute and recurrent urinary tract infection visiting a diagnostic laboratory in Lahore. The prevalence of MDR strains of E. coli among the isolates was also determined. A total of 310 isolates (73.1%) of E. coli were obtained from 424 positive culture isolates. The highest percentage of the isolates was present in the age group of 51- 75 years in both males and females (30.9% and 9.6% respectively). Females were more frequently affected (77.4%) as compared to males (22.5%, P < 0.02). E. coli showed highest sensitivity towards Imipenem (100%), Meropenem (99.3%), Piperacillin/Tazobactum (96.8%), Amikacin (89.7%), Cefoperazone/Sulbactum (86.8%), Ceftazidime (77.2%), Gentamicin (73.2%), and Aztreonam (67.1%). 65.5% of isolates were resistant to more than 8 drugs, belonging to 3 or more than 3 different classes of drugs.