The determination of sulphanilamide and its derivatives

Abstract

THE extensive use of sulphanilamide and its 'derivatives in medicine during the past few years has naturally led to the investigation of methods for the estima- tion of this group of drugs in blood, especially as it seems that a knowledge of' the blood level of the compound used is necessary for correct treatment. The work of Marshall et al. [1937] has shown that sulphanilamide is acetylated in the animal organism, and, since the therapeutic value is very considerably altered by this conjugation, a knowledge of the amount of this bound sulphanilamide