PubMed · 1966 · 28 citations · 0 references
MedicineEndocrinologyPharmacotherapyFertilityReproductive EndocrinologyReproductive MedicineContraceptive MethodsHormonal ContraceptionMenopause PharmacotherapyReproductive Endocrinology PharmacotherapyReproductive PharmacologySide EffectsClinician AcceptanceHormonal Contraceptive TherapyIrregular Uterine BleedingOral Estrogen TherapyReproductive Drug SafetySide Effect Profile
310 Mexican women were given single injections of 200-1000 mg of medroxyprogesterone acetate (MPA) or as a combination of 150 mg of MPA plus 40 mg estradiol polyphosphate to test the acceptability of an injectable method of fertility control. Pregnancies occurred in 3 women after a single injection 10-11 months previous to conception. The main side effect was unpredictable menstrual behavior. Supplementary oral estrogen was given to reestablish regular uterine bleeding. Other side effects did not constitute a significant factor in patient acceptance. Lactation was not interfered with by the drug.