European Conference on Information Systems · 2014 · 17 citations · 0 references
EngineeringDigital DesignManufacturing Engineering3D ModelingAdditive ManufacturingProduct Design3D PrintingDesign For Additive ManufacturingDigital Manufacturing3D Printed ModelsAdditive FabricationIndustrial ProductionThree-dimensional Printing
This serves as the first study to document the mechanisms of bone induction and fusion maturation between posterolateral arthrodeses treated with autograft versus rhOP-1. The histological data served to corroborate the radiographic and biomechanical findings, because the rhOP-1 treatments consistently demonstrated increased fusion rates and lower range of motion levels compared with the autograft group, particularly at the 8-week postoperative time period. The improvements in these fusion criteria for Osteogenic Protein-1 versus autograft were considered secondary to the differing mechanisms of bone induction. When implanted for posterolateral arthrodesis, rhOP-1 induces an intramembranous healing response, obviating the need for the cartilage intermediate phases found in endochondral bone development. The mechanism of increased speed and incidence of fusion using growth factors (rhOP-1) is delineated by this comprehensive study of preferential intramembranous ossification.