Spontaneous corneal neovascularization in nude mice. Local imbalance between angiogenic and anti-angiogenic factors.

Abstract

The results confirm that there is an imbalance between angiogenic and anti-angiogenic factors in the nude mouse cornea. The cornea of the nude mouse displays more angiogenic activity and less anti-angiogenic activity than that of the normal mouse. Most angiogenic activity of the nude mouse cornea appears to reside in the epithelium.