The Journal of Cell Biology · 1966 · 53 citations · 0 references
Life SciencesBiologyCell BiologyGene ExpressionNucleic Acid BiochemistryRna BiologyNuclear EnvelopeRna TranscriptionAmnion Biology
On the Primary Site of Nuclear RNA Synthesis" (2), in which we reported evidence in support of the view that all nuclear RNA (including nucleolar) is synthesized in the nonnucleolar regions of the nucleus of human amnion cells. Shortly thereafter, Sisken and Kinosita (3), Amano and Leblond (1), and others offered strong evidence for the conclusion that "chromosomal" RNA is synthesized in the nonnucleolar parts of the nucleus, and that nucleolar RNA is synthesized in the nucleolus. In the face of this contrary evidence, we repeated our experiments (in 1961) and were forced to conelude that our earlier report was erroneous, and that Sisken and Kinosita, Amano and Leblond, and others who contend that nucleolar RNA is synthesized in the nucleolus are correct.