A Facile Route to Triazole Dendrimers via Click Chemistry Linking Tripodal Acetylene and Dendrons

Abstract

Dendrimers are highly branched macromolecules, which are prepared by repetition of a given set of reactions using either divergent or convergent strategies.1 Generally, the reactions employed are high yielding without any side reactions. Well known processes, such as the Michael reac-tion, Williamson ether synthesis, amidations and reductions have been used extensively.2 Recent investigation of the click chemistry, the Cu(I)-catalyzed Huisgen [2 + 3] dipolar cycloaddition reaction between an organic azide and an alkyne, has attracted attention which has found many applications in organic chemistry,3 supramolecular chemistry,4 drug discovery,5 bioconjugations,6 and materials science.7 The reaction is characterized by very high yields, mild and simple reaction conditions, oxygen and water tolerance, and ease of product isolation. It is highly chemoselective