QT Interval: Correction for Heart Rate

Abstract

There are several empirically based pro- posals in the literature for adjusting QT intervals for heart rate. Two widely used correction formulas are Bazett's and Fridericia's. This study examines the general formulation of heart rate correc- tion of QT intervals, and several of the existing adjustments are used with this approach. Simple correction formulas for both populations and individuals have been derived on the basis that the correlation between corrected QT inter- val and heart rate should be approxi- mately zero. A Monte-Carlo simulation is used for comparing the performance of Bazett's, Fridericia's, and the pro- posed corrections. The usefulness of the proposed correction formula is illustrat- ed using data from a clinical trial.