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Alterations in retinal rod outer segment fatty acids and light-damage susceptibility in P23H rats.

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References

2002

Year

Ina Rea Bicknell, Ruth Darrow, Linda Barsalou, Steven J. Fliesler, Daniel T. Organisciak
PubMed

Abstract

Heterozygous P23H rats are capable of forming ROS DHA from dietary fatty acid precursors found in linseed oil (18:3n-3) or fish oil (20:5n-3). Under all dietary conditions, P23H transgenics are highly susceptible to retinal damage from exposure to intense light. Although levels of DHA in the ROS of P23H rats could be altered by dietary manipulation, only small changes in photoreceptor cell survival, as measured by whole-retina rhodopsin and DNA content, were observed. The lower-than-normal levels of ROS DHA may reflect an adaptive, possibly protective, mechanism in the P23H transgenic rat model of RP.