The aqueous humor drainage mechanism in the cynomolgus monkey (Macaca irus) with evidence for unconventional routes.

Abstract

centration after 1 minute, while throughout the experiments the diodone concentration in the effluent remained lower than expected from, a bulk flow through well-defined channels. The low concentration was due to a rapid diffusion of diodone into the tissues of the limbus region. The labeled albumin entered the uvea and the sclera in such amounts as to indicate that about 20 per cent of the labeled fluid had passed out by way of unconventional uveoscleral routes. The results suggest that more than 90 per cent of the conventional drainage was carried by pores xoith an apparent diameter of more than 0.16 n. t has been demonstrated in many ways that in the primate eye aqueous humor flows from the anterior chamber into Schlemm's canal. It is quite clear that the aqueous first passes into the spaces of the trabecular meshwork but how it then passes through the inner wall of Schlemm's canal is a matter of question. Much physiologic evidence 1 4 suggests that the flow occurs