Indian Journal of Pharmaceutical Sciences · 2003 · 10 citations · 0 references
PharmacyDental Biomaterials SciencePharmaceuticsDrug DeliveryOral Drug DeliveryPharmaceutical FormulationBuccal Drug DeliveryMucosal Formulation DesignAdhesion StrengthBuccal PatchesMucoadhesive Drug DeliveryMucoadhesive Drug Delivery SystemsMucoadhesive Drug FormulationsMucoadhesive FilmsMucoadhesive Oral FormulationsRelease Profile Characterization
The goal of the present investigation was to design and evaluate mucoadhesive buccal patches of diclofenac sodium, which is used as analgesic and antiinflammatory agent. Patches were fabricated by casting technique with different polymer combinations and were evaluated for in vitro release, bio-adhesion strength, duration of bioadhesion, folding endurance, surface pH and percentage of elongation. The release profile and test for adhesion were found to be the function of the type of polymer used. The formulation containing hydroxy propyl cellulose and carbapol 934 P was found to give the better results.