Cytogenetic damage analysed by the dicentric assay.

TLDR

Biological dosimetry using dicentric chromosome analysis is an internationally established, independent method for individual dose assessment, especially after unclear or suspected radiation exposures, and is increasingly challenged by potential large-scale radiation accidents involving many exposed persons. To prepare for efficient response to such accidents, cytogenetic laboratories have intensified national and international cooperation. Intercomparison experience shows current performance and suggests future options to increase sample throughput.

Abstract

Biological dosimetry, based on the analysis of dicentric chromosomes, is an internationally established, independent method applied in the area of radiation protection. The biodosimetry is mainly performed, in addition to physical dosimetry, with the aim of individual dose assessment, especially after unclear or suspected radiation dose exposures. However, a new biodosimetrical challenge has emerged in recent years in the form of a possible large scale radiation accident potentially involving large numbers of exposed persons. In order to be prepared to act in an efficient manner in such an accident, the established cytogenetic laboratories have increased their cooperation at the national and international level. General experience and results of intercomparisons are reported and future options to increase sample throughput are outlined.