PubMed · 2006 · 11 citations · 0 references
MedicineNeurosciencePharmacologyDrug DeliveryNeurochemistryNeuropharmacologyDopaminergic PharmacologyNeurochemical PharmacologyNeurodegenerative Disease PharmacotherapyNeuroprotectionNeuroprotective PharmacologyParkinson DiseaseDopamine OxidationDopaminergic NeuroprotectionNeuroprotective AgentsNeuroprotective ResponsesParkinson's Disease PharmacotherapyParkinson’s Disease PharmacotherapyQuinone FormationQuinone Metabolism
The objective of this study was to determine the effects of thymoquinone on the viability and metabolic activity of SH-SY5Y human neuroblastoma cells alone or challenged with levodopa (L-dopa) using conventional and sustained drug delivery routes. The findings suggest that thymoquinone may protect SH-SY5Y cells against L-dopa toxicity to some degree although the exact mechanism for this is unknown. Thymoquinone may be a viable option to prevent quinone formation as a result of L-dopa auto-oxidation and could be investigated as a neuroprotective agent given the fact that inflammatory etiologies are strongly implemented in the pathogenesis of Parkinson's disease.