Humoral antibodies and coagulation mechanisms in the accelerated or hyperacute rejection of renal homografts in sensitized canine recipients.

Abstract

Dogs were sensitized with repeated skin homotransplantation and then given a spleen, kidney, or liver from their skin donor. Coincident with sensitization, there developed a family of anti–donor antibodies which apparently participated in the accelerated or hyperacute rejection of the whole organs. An important component of the destructive process was a coagulopathy which always occurred within the grafts and which sometimes led to systemic alterations resembling a disseminated intravascular coagulation. Kidneys were usually temporarily protected from hyperacute rejection by the prior transplantation of another organ (kidney, spleen, or liver) from the same donor.