Analgesic and antipyretic activities of Dalbergia sissoo leaves

Abstract

Objective: To evaluate the analgesic and antipyretic activities of alcoholic extract of Dalbergia sissoo leaves. Methods: The peripheral analgesic activity of Dalbergia sissoo leaves (SLE; 100, 300 and 1000 mg/kg) was studied using acetic acid induced writhing in mice and by Randall-Selitto assay. The central analgesic activity of SLE was studied using hot-plate method and tail clip test in mice. The antipyretic activity of SLE was studied in Brewer's yeast-induced pyrexia in rats. Results: SLE significantly decreased the writhing movements in mice in acetic acid-induced writhing test. SLE (1000 mg/kg) significantly increased the pain threshold capacity in rats in Randall-Selitto assay and the reaction time in hot-plate test but not in tail-clip test. It also showed significant antipyretic activity in Brewer's yeast-induced pyrexia in rats throughout the observation period of 6 h. Conclusion: SLE may have analgesic and antipyretic activities.