Long-Term Diuretic Therapy in Hypertensive Patients: Effects on Serum Homocysteine, Vitamin B6, Vitamin B12, and Red Blood Cell Folate Concentrations

Abstract

Chronic diuretic use is associated with a significant increase in serum homocysteine concentration, a significant decrease in RBC folate concentration, and no significant change in concentrations of vitamins B6 and B12.