Fully intermittent six month regimens for pulmonary tuberculosis in south India

Abstract

A large-scale multi-centric study in
\nSouth India was organised by the Tuberculosis
\nResearch Centre, Madras. The regimens
\nc o n s i s t e d o f Rifampicin, Isoniazid,
\nStreptomycin and Pyrazinamide, administered
\nunder supervision, twice or thrice a week for
\nthe first 2 months, followed by different
\ncombinations of 2 or 3 drugs administered
\ntwice or once a week for the next 4 months. The
\npatients were followed up with intensive
\nbacteriological examination. The response at
\nthe end of chemotherapy and the relapse rates
\nduring a 4½-year follow-up in approximately
\n1,000 patients with drug-sensitive organisms
\ninitially and 200 patients with organisms
\ninitially drug resistant are presented.