Attempt to fulfil Koch's postulates for pyloric Campylobacter

TLDR

Acute pyloric Campylobacter gastritis is a recognized syndrome. The study proposes that acute pyloric Campylobacter gastritis may progress to a chronic infection that predisposes to peptic ulceration. A volunteer with normal gastric mucosa was orally inoculated with pyloric Campylobacter. The volunteer developed a mild 14‑day illness and transient gastritis that resolved by day 14.

Abstract

A volunteer with histologically normal gastric mucosa received pyloric Campylobacter by mouth. A mild illness developed, which lasted 14 days. Histologically proven gastritis was present on the tenth day after the ingestion of bacteria, but this had largely resolved by the fourteenth day. The syndrome of acute pyloric Campylobacter gastritis is described. It is proposed that this disorder may progress to a chronic infection which predisposes to peptic ulceration.