The formation of mercapturic acids. 3. <i>N</i>-Acetylation of <i>S</i>-substituted cysteines in the rabbit, rat and guinea pig

Abstract

1. Increased synthesis of actinomycins II and III occurred when sarcosine was added to the medium of growing cultures of StreptomyceB antibioticus. The amount of actinomycins II and III formed depends, in part, on the concentration of sarcosine and on the time and the number of additions of this amino acid. Mycelial actino- mycin, as well as that produced in the medium, contains considerable amounts of actinomycins II and III.