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Brief Communication : Adriamycin-Induced Cardiac Damage in the Mouse: A Small-Animal Model of Cardiotoxicity
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1975
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Mitochondrial DegenerationCardiac MuscleHeart FailureCardiovascular PharmacologyPathologyCardiovascular ToxicityOxidative StressAdriamycin-induced Cardiac DamageElectron MicroscopySmall-animal ModelBrief CommunicationCardiologyCardiomyopathyPharmacologyCardiac PathologyCardiovascular DiseasePhysiologyFatal ToxicityMedicine
After one dose of adriamycin, a subacute cardiomyopathy was observed in the mouse by both light and electron microscopy. The microscopic alterations were characterized by single-cell necrosis and mitochondrial degeneration. These lesions were similar to those seen in man and shortly preceded fatal toxicity.