PubMed · 1996 · 108 citations · 0 references
Veterinary MedicineMicrobiologyPathobiologyGastrointestinal Critical CareMicrobial PathogenesisSepsisGastrointestinal PathophysiologyGastrointestinal SepsisIntestinal Barrier FunctionSepsis ManagementSepsis PathophysiologySeptic ShockBarrier Disruption MechanismsGastrointestinal Barrier DysfunctionGut Barrier DisruptionGut Barrier FunctionIntestinal Mucosal InjuryMicrobial TranslocationMucosal Barrier DisruptionShock-induced Bacterial Translocation
This article reviews the scientific and clinical evidence that supports trauma and shock as potential etiologies for translocation of intestinal microorganisms and their by-products. The potential for loss of intestinal barrier function to cause the eventual septic deaths observed in such patients, as well as possible mechanisms for preventing and treating this entity is also discussed.